Formulation design of the oral disintegrating tablets including alfuzosin hydrochloride with risk evaluation via quality by design
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چکیده
منابع مشابه
Formulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions
Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...
متن کاملFormulation of Desloratadine Oral Disintegrating Tablets
Article history: Received on: 13/08/2014 Revised on: 09/09/2014 Accepted on: 15/10/2014 Available online: 27/11/2014 Desloratadine (DS) is a tricyclic antihistaminic, characterized by bitter taste and slight water solubility. The aim of this study is to prepare DS as orally disintegrating tablets (ODT) to mask the bitter taste and improve compliance. Twelve different placebo ODT (F1-F12) were p...
متن کاملFormulation Design of Novel Fast Disintegrating Tablets of Prochlorperazine Maleate
In the present work, fast disintegrating tablets of prochlorperazine maleate were prepared with a view to enhance patient compliance by direct compression method. Three superdisintegrants i.e., crospovidone, croscarmellose sodium and sodium starch glycolate in different ratios with MCC (Avicel, PH-102) along with directly compressible mannitol (Pearlitol SD 200) to enhance mouth feel. The prepa...
متن کاملFormulation Design of Fast Disintegrating Tablets Using Disintegrant Blends
In the present work, fast disintegrating tablets of prochlorperazine maleate were designed with a view to enhance patient compliance by direct compression method. In this method, crospovidone (up to 3% w/w) and croscarmellose sodium (up to 5% w/w) in combination were used as superdisintegrants. Since disintegrants complement each other, accelerating the disintegration process when used together...
متن کاملOptimization and Formulation Design with In-Vitro Evaluation of Fast Disintegrating Tablets Containing Candesartan Solid Dispersions
The aim of this study was to assess the effects of processing parameters on the release of solid dispersion formulation from a fast dissolving tablet dosage form. Graphical and mathematical analysis such as the response surface methodology (RSM) and multiple response optimizations utilizing the polynomial equation were used to search for the optimal formulation and to quantify the effect of eac...
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ژورنال
عنوان ژورنال: ACTA Pharmaceutica Sciencia
سال: 2017
ISSN: 1307-2080
DOI: 10.23893/1307-2080.aps.05512